In 1963, Jewish hospital was accepted as a major affiliate of Washington University.
In the early 1960s, Barnes became only the third hospital in the country to use the heart-lung bypass machine during open-heart surgery.
The hospital built a cyclotron in 1963 to enhance radiologic imaging and radiation treatments at the hospital. Also that year, Dr. William Newton performed the first kidney transplant in the Midwest.
Seventeen-story Queeny Tower, named for benefactor Edgar Monsanto Queeny, opened in 1965. The Tower pioneered a new approach to patient care: treating the patient as a whole person, not merely a bundle of medical needs.
During this time, Barnes was also earning a national reputation for burn and trauma care, with an innovative burn treatments and a dedicated burn center under the direction of Dr. William Monafo.