THESE CLIPS FROM A VIDEO REVEALS A MOMENT IN THE REAL-TIME PROGRESSION OF A SINGLE UTERINE CONTRACTION DURING NORMAL LABOR.

 

Images courtesy of Wang Lab

BY JACQUELYN KAUFFMAN

Building on imaging methods long used on the heart, researchers have developed a new technology that can produce 3D maps showing the magnitude and distribution of uterine contractions in real time and across the entire surface of the uterus during labor.

Current tools can only indicate the presence or absence of a contraction. Building on imaging methods long used on the heart, an investigational version of the technology can image uterine contractions noninvasively and in much greater detail than currently available tools.

The new method was developed by researchers at Washington University School of Medicine in St. Louis and was evaluated in a clinical study that included 10 participants in active labor. Results of the study were published March 14 in the journal Nature Communications.

“There are all kinds of obstetrics and gynecological conditions that are associated with uterine contractions, but we don’t have very accurate ways of measuring them,” says the study’s senior author, Yong Wang, PhD, a Washington University scientist specializing in obstetrics and gynecology, electrical and systems engineering, radiology and biomedical engineering. “With this new imaging technology, we are basically upgrading the standard way of measuring labor contractions—called tocodynamometry—from one-dimensional tracing to four-dimensional mapping. This kind of information could help improve care for patients with high-risk pregnancies and identify ways to prevent preterm birth, which occurs in about 10% of pregnancies globally.”

During labor and birth, the uterus contracts to provide the force that expels the baby, and the new method for measuring these contractions is called electromyometrial imaging, or EMMI. This new method could, for example, help identify the types of early contractions that lead to birth and help researchers identify ways to slow down or stop these preterm contractions. Abnormalities in contractions also can lead to labor arrest, which can necessitate a Cesarean (C-section) delivery. Preterm birth and C-sections can increase the risk of birth complications or death for both mother and infant. Such complications can lead to long-term neurodevelopmental disability for the child.

Analyzing data from the trial, the researchers found that uterine contractions are less predictable and consistent than the heart contractions that are typically measured with similar technology. Even in the same person, consecutive labor contractions may differ in the initiating region and the direction of progression. Further, the researchers found that there are no consistent areas of the uterus in which contractions begin, indicating that the initiation sites, or pacemakers, of uterine contractions are not anatomically fixed, as they are in the heart. These considerations add more value to the new imaging technology, as it can track changes through progressive contractions.

The study included women who were giving birth for the first time and some who had given birth before. The researchers found that study participants who had not given birth before had longer contractions with more variation compared with those who previously had given birth. This is indicative of a possible memory effect of the uterus. In those who previously have given birth, the uterus appears to remember its past labor experience and has more efficient and productive contractions.

Wang notes that EMMI has the potential to:

• Distinguish productive versus nonproductive contractions to predict preterm birth in women with preterm contractions
• Monitor labor contractions in real time to optimize pharmaceutical treatment and prevent labor complications, including when labor stalls
• Monitor uterine contractions to prevent postpartum hemorrhage
• Develop possible nonpharmaceutical treatment, including mild electrical interventions to normalize contraction patterns
• Investigate uterine-related conditions outside of pregnancy, including painful menstruation and endometriosis

The next step of Wang’s research is to measure normal uterine contractions that would help decipher whether a contraction is productive and leading toward birth. Last year, his team received a grant from the National Institutes of Health (NIH) to create an atlas of sorts that characterizes what contractions during normal labor look like.

“The goal of this grant is to image healthy term labor in 300 patients so that we know what the normal range looks like—for first-time births and second- or third-time births,” Wang says. “This is a new measurement, so we don’t have a previous accumulation of knowledge. We have to produce a normal baseline atlas first.”

In resource-poor areas, this type of detailed imaging could help make labor and childbirth safer. To make the technology more accessible, Wang is aiming to use less expensive and more portable ultrasound imaging instead of costly MRI scans, which are not widely accessible in many parts of the world. In addition, Wang’s team is in the process of producing disposable electrodes and wireless transmitters in close collaboration with Washington University colleagues Chuan Wang, PhD, and Shantanu Chakrabartty, PhD, with the support of the Bill & Melinda Gates Foundation.

“We would like to develop a low-cost EMMI system that can be applicable in low- and moderate-resource settings,” Yong Wang says. “We are trying to make the electrodes much cheaper using printed, disposable electrodes and a wireless transmitter.”

Originally published by Washington University School of Medicine at medicine.wustl.edu/news.